The current literature indicates that osteopathic manipulative treatment may offer benefits in reducing pain and improving function in individuals with chronic and nonspecific neck pain, including stiffness as a symptom. Some mechanistic evidence supports measurable changes in muscle tissue properties. However, the overall quality of evidence is low to moderate, with significant research gaps. While clinical experience and some controlled data suggest potential utility, definitive evidence supporting OMT as a first-line intervention for neck stiffness requires further high-quality research.