Grisel’s Syndrome is a rare but potentially serious condition characterized by non-traumatic atlantoaxial rotatory subluxation, usually following upper respiratory infections or ear, nose, and throat procedures. Patients commonly present with painful torticollis, neck stiffness, and restricted cervical motion. Early diagnosis using clinical assessment and imaging is essential to prevent neurological complications. Treatment typically includes antibiotics, anti-inflammatory medication, cervical immobilization, and rehabilitation. Osteopathic treatment may help restore function and reduce muscle tension once cervical instability has been medically stabilized.